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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| PANOBINOSTAT DISCONTINUED
| PANOBINOSTAT | ANTINEOPLASTIC | ORAL | Tmax 2 HOUR F 21 PERCENT VD 8542 LITER (EQN) PPB 90 PERCENT Cl 160 LITER / HOUR HT 37 HOUR SOLUBILITY SLIGHTLY SOLUBLE IN WATER | HISTONE DEACETYLASE PDB 5EF8 (CRYSTAL STRUCTURE OF DANIO RERIO HISTONE DEACETYLASE 6 CATALYTIC DOMAIN 2 IN COMPLEX WITH PANOBINOSTAT) LIGAND CODE = LBH (link to the list of PDB complexes) Download experimental 3D coordinates of LBH with added hydrogens | Histone deacetylase 5 UNIPROT Q9UQL6 HDAC5 -- Histone deacetylase 2 UNIPROT Q92769 HDAC2 more at DrugCentral | EMA | |||
