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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| BELINOSTAT
| BELINOSTAT | ANTINEOPLASTIC | INTRAVENOUS | VD 40 LITER PPB 94.3 PERCENT Cl 74.4 LITER / HOUR HT 1.1 HOUR SOLUBILITY SLIGHTLY SOLUBLE IN DISTILLED WATER (0.14 MILLIGRAM / MILLILITER) | HISTONE DEACETYLASE (HDAC) PDB 5EEN (CRYSTAL STRUCTURE OF DANIO RERIO HISTONE DEACETYLASE 6 CATALYTIC DOMAIN 2 IN COMPLEX WITH BELINOSTAT) LIGAND CODE = 5OG (link to the list of PDB complexes) Download experimental 3D coordinates of 5OG with added hydrogens | Histone deacetylase 5 UNIPROT Q9UQL6 HDAC5 -- Histone deacetylase 2 UNIPROT Q92769 HDAC2 more at DrugCentral | EMA | |||
