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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
EMPAGLIFLOZIN

EMPAGLIFLOZIN


ATC A10BK03
ATC A10BD19
ATC A10BD20
ATC A10BD27

METABOLISM
TREATMENT OF TYPE 2 DIABETES MELLITUS
SODIUM-GLUCOSE CO-TRANSPORTER2 (SGLT2) INHIBITOR

ORAL

Cmax 687 NANOMOLAR

Tmax 1.5 HOUR

VD 73.8 LITER

PPB 86.2 PERCENT

Cl 10.6 LITER / HOUR

HT 12.4 HOUR

SOLUBILITY VERY SLIGHTLY SOLUBLE IN WATER

SODIUM-GLUCOSE CO-TRANSPORTER2 (SGLT2)

PDB 7Y0B (CRYSTAL STRUCTURE OF HUMAN SHORT-CHAIN ACYL-COA DEHYDROGENASE)

LIGAND CODE = 7R3 (link to the list of PDB complexes)

Download experimental 3D coordinates of 7R3 with added hydrogens

Sodium,glucose cotransporter 2 UNIPROT P31639 SLC5A2

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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