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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| DAPAGLIFLOZIN
| DAPAGLIFLOZIN |
METABOLISM | ORAL | Tmax 2 HOUR F 78 PERCENT PPB 91 PERCENT HT 12.9 HOUR | SODIUM-GLUCOSE COTRANSPORTER 2 (SGLT2) PDB 8HEZ (STRUCTURE OF HUMAN SGLT2-MAP17 COMPLEX WITH DAPAGLIFLOZIN) LIGAND CODE = LE6 (link to the list of PDB complexes) Download experimental 3D coordinates of LE6 with added hydrogens | Sodium,glucose cotransporter 2 UNIPROT P31639 SLC5A2 more at DrugCentral | EMA | |||
