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INN

Class

Route (list)

PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)

Primary Target and PDB code of Protein-Drug complex

Targets from DrugCentral

Links

DALBAVANCIN

ATC J01XA04

ANTIINFECTIVES
TREATMENT OF FOR ACUTE BACTERIAL SKIN AND SKIN STRUCTURE INFECTIONS
LIPOGLYCOPEPTIDE SYNTHESIZED FROM A FERMENTATION PRODUCT OF NONOMURAEA SPECIES
A MIXTURE OF FIVE CLOSELY RELATED ACTIVE HOMOLOGS (A0, A1, B0, B1 AND B2)
B0 IS THE MAJOR COMPONENT OF DALBAVANCIN
INTERFERES WITH CELL WALL SYNTHESIS BY BINDING TO THE D-ALANYL-D-ALANINE TERMINUS OF THE STEM PENTAPEPTIDE IN NASCENT CELL WALL PEPTIDOGLYCAN

INTRAVENOUS

Cmax 158 MICROMOLAR (1000 MILLIGRAM)

VD 25.6 LITER (EQN)

PPB 93 PERCENT

Cl 0.0513 LITER / HOUR

HT 346 HOUR

PEPTIDOGLYCAN PRECURSORS

PDB 3RUL (A CARRIER PROTEIN STRATEGY YIELDS THE STRUCTURE OF DALBAVANCIN)

Unknown

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank