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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| VORAPAXAR DISCONTINUED
| VORAPAXAR | BLOOD | ORAL | Tmax 1 HOUR F 100 PERCENT VD 424 LITER PPB 99 PERCENT Cl 1.5 LITER / HOUR (EQN) HT 192 HOUR SOLUBILITY SLIGHTLY SOLUBLE IN WATER AT PH 1 | PROTEASE-ACTIVATED RECEPTOR-1 (PAR-1) PDB 3VW7 (CRYSTAL STRUCTURE OF HUMAN PROTEASE-ACTIVATED RECEPTOR 1 (PAR1) BOUND WITH ANTAGONIST VORAPAXAR AT 2.2 ANGSTROM) LIGAND CODE = VPX (link to the list of PDB complexes) Download experimental 3D coordinates of VPX with added hydrogens | Proteinase-activated receptor 1 UNIPROT P25116 F2R more at DrugCentral | EMA | |||
