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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
M MISOPROSTOL (is an active metabolite)

MISOPROSTOL


ATC A02BB01
ATC G02AD06
ATC M01AE56

METABOLISM
ANTIULCERATIVE
PROSTAGLANDINS
SYNTHETIC PROSTAGLANDIN E1 ANALOG

-

Cmax 2.2 NANOMOLAR

Tmax 0.2 HOUR

PPB 90 PERCENT

HT 0.5 HOUR

PROSTAGLANDIN RECEPTOR

PDB 6M9T (CRYSTAL STRUCTURE OF EP3 RECEPTOR BOUND TO MISOPROSTOL-FA)

LIGAND CODE = J9P (link to the list of PDB complexes)

Download experimental 3D coordinates of J9P with added hydrogens

Prostaglandin E2 receptor EP3 subtype UNIPROT P43115 PTGER3

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
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Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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