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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| FOSINOPRILAT (is an active metabolite)
| FOSINOPRILAT | CARDIOVASCULAR | - | Tmax 3 HOUR VD 8.45 LITER (65 KILOGRAM) PPB 99.4 PERCENT Cl 1.95 LITER / HOUR HT 12 HOUR | ANGIOTENSIN-CONVERTING ENZYME PDB 7Z6Z (CRYSTAL STRUCTURE OF ANGIOTENSIN-1 CONVERTING ENZYME N-DOMAIN IN COMPLEX WITH FOSINOPRILAT) LIGAND CODE = KS8 (link to the list of PDB complexes) Download experimental 3D coordinates of KS8 with added hydrogens | Angiotensin-converting enzyme UNIPROT P12821 ACE more at DrugCentral | EMA | |||
