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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| TRAMADOL (has an active metabolite)
| TRAMADOL |
NERVOUS SYSTEM | ORAL | Cmax 2.25 MICROMOLAR Tmax 2.3 HOUR F 75 PERCENT VD 188 LITER (65 KILOGRAM) PPB 20 PERCENT Cl 23 LITER / HOUR (65 KILOGRAM) HT 6.7 HOUR SOLUBILITY READILY SOLUBLE IN WATER (LOGP=1.35) | MU-TYPE OPIOID RECEPTOR PDB 6M47 (X-RAY STRUCTURE OF A DROSOPHILA DOPAMINE TRANSPORTER WITH NET-LIKE MUTATIONS (D121G, S426M, F471L) IN TRAMADOL BOUND FORM) LIGAND CODE = F1U (link to the list of PDB complexes) Download experimental 3D coordinates of F1U with added hydrogens | Mu-type opioid receptor UNIPROT P35372 OPRM1 more at DrugCentral | EMA | |||
