| | ||||||||||
| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| M GEMCITABINE (is an active metabolite)
| GEMCITABINE | ANTINEOPLASTIC | - | DEOXYCYTIDINE KINASE PDB 3MDC (DNA POLYMERASE LAMBDA IN COMPLEX WITH DFDCTP) LIGAND CODE = GTF (link to the list of PDB complexes) Download experimental 3D coordinates of GTF with added hydrogens | Ribonucleoside-diphosphate reductase large subunit UNIPROT P23921 RRM1 -- Ribonucleoside-diphosphate reductase subunit M2 UNIPROT P31350 RRM2 more at DrugCentral | EMA | ||||
