M TETRABENAZINE (is an active metabolite) | TETRABENAZINE | ATC N07XX06
NERVOUS SYSTEM CNS TREATMENT OF CHOREA ASSOCIATED WITH HUNTINGTON DISEASE INHIBITOR IS BELIEVED TO BE RELATED TO ITS EFFECT AS A REVERSIBLE DEPLETOR OF MONOAMINES (SUCH AS DOPAMINE, SEROTONIN, NOREPINEPHRINE, AND HISTAMINE) FROM NERVE TERMINALS VESICULAR MONOAMINE TRANSPORTER TYPE 2 (VMAT2) (KI=100 NANOMOLAR) | - | Tmax 1 HOUR PPB 64 PERCENT HT 7 HOUR | VESICULAR MONOAMINE TRANSPORTER TYPE 2 (VMAT2) | Synaptic vesicular amine transporter UNIPROT Q05940 SLC18A2 more at DrugCentral | EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank |