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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| BAZEDOXIFENE
| BAZEDOXIFENE | GENITO | ORAL | Cmax 14.6 NANOMOLAR F 6 PERCENT VD 882 LITER (60 KILOGRAM) PPB 98 PERCENT Cl 24 LITER / HOUR (60 KILOGRAM) HT 30 HOUR SOLUBILITY PH DEPENDENT IN WATER (923 MICROGRAM / MILLILITER AT PH 5.4) | ESTROGEN RECEPTOR ALPHA ESTROGEN RECEPTOR BETA PDB 4XI3 (ESTROGEN RECEPTOR ALPHA LIGAND BINDING DOMAIN IN COMPLEX WITH BAZEDOXIFENE) LIGAND CODE = 29S (link to the list of PDB complexes) Download experimental 3D coordinates of 29S with added hydrogens | Estrogen receptor UNIPROT P03372 ESR1 -- Estrogen receptor beta UNIPROT Q92731 ESR2 more at DrugCentral | EMA | |||
