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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| IBRUTINIB
| IBRUTINIB | ANTINEOPLASTIC | ORAL | VD 10000 LITER PPB 97.3 PERCENT Cl 1000 LITER / HOUR HT 5 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | BRUTON TYROSINE KINASE (BTK) PDB 4IFG (CRYSTAL STRUCTURE OF TGCDPK1 WITH INHIBITOR BOUND) LIGAND CODE = 1E8 (link to the list of PDB complexes) Download experimental 3D coordinates of 1E8 with added hydrogens | Tyrosine-protein kinase BTK UNIPROT Q06187 BTK more at DrugCentral | EMA | |||
