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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| DOLUTEGRAVIR
| DOLUTEGRAVIR |
ANTIINFECTIVES | ORAL | Cmax 9.9 MICROMOLAR VD 17.4 LITER PPB 98.9 PERCENT Cl 1 LITER / HOUR HT 14 HOUR SOLUBILITY SLIGHTLY SOLUBLE IN WATER | HIV-1 INTEGRASE PDB 3S3O (CRYSTAL STRUCTURE OF THE PROTOTYPE FOAMY VIRUS (PFV) N224H MUTANT INTASOME IN COMPLEX WITH MAGNESIUM AND DOLUTEGRAVIR (S, GSK1349572)) LIGAND CODE = DLU (link to the list of PDB complexes) Download experimental 3D coordinates of DLU with added hydrogens | Integrase UNIPROT Q7ZJM1 pol more at DrugCentral | EMA | |||
