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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
LEVOMILNACIPRAN

LEVOMILNACIPRAN


ATC N06AX17

NERVOUS SYSTEM
TREATMENT OF MAJOR DEPRESSIVE DISORDER
SEROTONIN (KI=11 NANOMOLAR) AND NOREPINEPHRINE (KI=91 NANOMOLAR) REUPTAKE INHIBITOR

ORAL

Cmax 1.38 MICROMOLAR

F 92 PERCENT

VD 430 LITER

PPB 22 PERCENT

Cl 25 LITER / HOUR

HT 12 HOUR

SEROTONIN TRANSPORTER
NOREPINEPHRINE TRANSPORTER

Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 -- Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2

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