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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
MACITENTAN (has an active metabolite)

MACITENTAN


ATC C02KX04
ATC C02KX54

CARDIOVASCULAR
ANTIHYPERTENSIVE
PULMONARY ARTERIAL HYPERTENSION (PAH)
ENDOTHELIN RECEPTOR ANTAGONIST ET-1
PREVENTS THE BINDING OF ET-1 TO ITS RECEPTORS ETA AND ETB

ORAL

VD 50 LITER

PPB 99 PERCENT

Cl 2.1 LITER / HOUR (EQN)

HT 16 HOUR

SOLUBILITY NOT SOLUBLE IN WATER

ENDOTHELIN RECEPTOR ET-1

Endothelin-1 receptor UNIPROT P25101 EDNRA -- Endothelin B receptor UNIPROT P24530 EDNRB

more at DrugCentral

EMA

ANSM (in French)

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Drugs.com

SIDER side effects

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ChEMBL
BindingDB
DrugBank



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