| | ||||||||||
| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| CANAGLIFLOZIN
| CANAGLIFLOZIN | METABOLISM | ORAL | F 65 PERCENT VD 119 LITER PPB 99 PERCENT Cl 11.5 LITER / HOUR HT 13.1 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER FROM PH 1.1 TO 12.9 | SODIUM-GLUCOSE CO-TRANSPORTER 2 (SGLT2) PDB 8HDH (STRUCTURE OF HUMAN SGLT2-MAP17 COMPLEX WITH CANAGLIFLOZIN) LIGAND CODE = L3R (link to the list of PDB complexes) Download experimental 3D coordinates of L3R with added hydrogens | Sodium,glucose cotransporter 2 UNIPROT P31639 SLC5A2 more at DrugCentral | EMA | |||
