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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| BOSUTINIB
| BOSUTINIB | ANTINEOPLASTIC | ORAL | Cmax 0.37 MICROMOLAR VD 6080 LITER PPB 94 PERCENT Cl 189 LITER / HOUR HT 22.5 HOUR SOLUBILITY ABOVE PH 5 THE SOLUBILITY OF BOSUTINIB MONOHYDRATE REDUCES RAPIDLY | BCR-ABL PDB 4OTW (HER3 PSEUDOKINASE DOMAIN BOUND TO BOSUTINIB) LIGAND CODE = DB8 (link to the list of PDB complexes) Download experimental 3D coordinates of DB8 with added hydrogens | Tyrosine-protein kinase ABL1 UNIPROT P00519 ABL1 -- Proto-oncogene tyrosine-protein kinase Src UNIPROT P12931 SRC more at DrugCentral | EMA | |||
