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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| TOFACITINIB
| TOFACITINIB | IMMUNOMODULATING | ORAL | F 74 PERCENT VD 87 LITER PPB 40 PERCENT Cl 20 LITER / HOUR (EQN) HT 3 HOUR SOLUBILITY FREELY SOLUBLE IN WATER | JANUS KINASES (JAK) PDB 3LXK (STRUCTURAL AND THERMODYNAMIC CHARACTERIZATION OF THE TYK2 AND JAK3 KINASE DOMAINS IN COMPLEX WITH CP-690550 AND CMP-6) LIGAND CODE = MI1 (link to the list of PDB complexes) Download experimental 3D coordinates of MI1 with added hydrogens | JAK1,TYK2 UNIPROT P23458 JAK1 -- JAK2,TYK2 UNIPROT O60674 JAK2 more at DrugCentral | EMA | |||
