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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
ACLIDINIUM

ACLIDINIUM


ATC R03BB05
ATC R03AL05

RESPIRATORY SYSTEM
ANTICHOLINERGIC
MUSCARINIC RECEPTOR ANTAGONIST
CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)
INHIBITION OF M3 RECEPTOR AT THE SMOOTH MUSCLE LEADING TO BRONCHODILATION

INHALATION

Tmax 0.16 HOUR

F 6 PERCENT

VD 300 LITER (INTRAVENOUS ADMINISTRATION OF 400 MCG)

Cl 170 LITER / HOUR

HT 6.5 HOUR

SOLUBILITY VERY SLIGHTLY SOLUBLE IN WATER

MUSCARINIC RECEPTORS (M1 TO M5)

Muscarinic acetylcholine receptor M3 UNIPROT P20309 CHRM3

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