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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| REGORAFENIB
| REGORAFENIB | ANTINEOPLASTIC | ORAL | Cmax 5.1 MICROMOLAR Tmax 4 HOUR F 76 PERCENT PPB 99.5 PERCENT HT 28 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | RET VEGFR1 VEGFR2 VEGFR3 KIT PDGFR-ALPHA PDGFR-BETA FGFR1 FGFR2 TIE2 DDR2 TRKA RAF-1 BRAF BRAF(V600E) SAPK2 PTK5 ABL | Serine,threonine-protein kinase B-raf UNIPROT P15056 BRAF -- Vascular endothelial growth factor receptor 2 UNIPROT P35968 KDR more at DrugCentral | EMA | |||
