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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| MIRABEGRON
| MIRABEGRON | GENITO | ORAL | F 29 PERCENT VD 1670 LITER PPB 71 PERCENT Cl 57 LITER / HOUR HT 50 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER 0.082 MILLIGRAM / MILLILITER | BETA-3 ADRENERGIC RECEPTOR PDB 7DH5 (DOG BETA3 ADRENERGIC RECEPTOR BOUND TO MIRABEGRON IN COMPLEX WITH A MINIGS HETEROTRIMER) LIGAND CODE = H6U (link to the list of PDB complexes) Download experimental 3D coordinates of H6U with added hydrogens | Beta-3 adrenergic receptor UNIPROT P13945 ADRB3 more at DrugCentral | EMA | |||
