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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
PASIREOTIDE

PASIREOTIDE


ATC H01CB05

HORMONES
CUSHING’S DISEASE
SOMATOSTATIN ANALOGUE
HUMAN SOMATOSTATIN RECEPTORS (HSST) AGONISTS
LEADS TO DECREASED CORTISOL SECRETION
HSST1 (IC50 = 9.3 NANOMOLAR)
HSST2 (IC50 = 1.0 NANOMOLAR)
HSST3 (IC50 = 1.5 NANOMOLAR)
HSST4 (IC50 > 1000 NANOMOLAR)
HSST5 (IC50 = 0.16 NANOMOLAR)

SUBCUTANEOUS INTRAMUSCULAR

VD 100 LITER

PPB 88 PERCENT

Cl 7.6 LITER / HOUR

HT 12 HOUR

SOMATOSTATIN RECEPTORS (SST)

Somatostatin receptor type 2 UNIPROT P30874 SSTR2 -- Somatostatin receptor type 3 UNIPROT P32745 SSTR3

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