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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| CABOZANTINIB
| CABOZANTINIB | ANTINEOPLASTIC | ORAL | VD 349 LITER PPB 99.7 PERCENT Cl 4.4 LITER / HOUR HT 55 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN AQUEOUS MEDIA | RET MET VEGFR-1 VEGFR-2 VEGFR-3 KIT TRKB FLT-3 AXL TIE-2 | Mast,stem cell growth factor receptor Kit UNIPROT P10721 KIT -- Receptor-type tyrosine-protein kinase FLT3 UNIPROT P36888 FLT3 more at DrugCentral | EMA | |||
