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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
CABOZANTINIB

CABOZANTINIB


ATC L01EX07

ANTINEOPLASTIC
TREATMENT OF PATIENTS WITH PROGRESSIVE METASTATIC MEDULLARY THYROID CANCER
INHIBITOR OF TYROSINE KINASE

ORAL

VD 349 LITER

PPB 99.7 PERCENT

Cl 4.4 LITER / HOUR

HT 55 HOUR

SOLUBILITY PRACTICALLY INSOLUBLE IN AQUEOUS MEDIA

RET
MET
VEGFR-1
VEGFR-2
VEGFR-3
KIT
TRKB
FLT-3
AXL
TIE-2

Mast,stem cell growth factor receptor Kit UNIPROT P10721 KIT -- Receptor-type tyrosine-protein kinase FLT3 UNIPROT P36888 FLT3

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