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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
ICOSAPENT (is an active metabolite)

ICOSAPENTNATURAL MOLECULE (link)

CARDIOVASCULAR
ADJUNCT TO DIET TO REDUCE TRIGLYCERIDE (TG) LEVELS IN ADULT PATIENTS WITH SEVERE (>= 500 MG/DL) HYPERTRIGLYCERIDEMIA
POTENTIAL MECHANISMS OF ACTION INCLUDE INCREASED BETA-OXIDATION
INHIBITION OF ACYL-COA:1,2-DIACYLGLYCEROL ACYLTRANSFERASE (DGAT)
DECREASED LIPOGENESIS IN THE LIVER
AND INCREASED PLASMA LIPOPROTEIN LIPASE ACTIVITY

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VD 88 LITER

PPB 99 PERCENT

Cl 0.68 LITER / HOUR

HT 89 HOUR

PDB 1IGX (CRYSTAL STRUCTURE OF EICOSAPENTANOIC ACID BOUND IN THE CYCLOOXYGENASE CHANNEL OF PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE-1.)

LIGAND CODE = EPA (link to the list of PDB complexes)

Download experimental 3D coordinates of EPA with added hydrogens

Unknown

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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