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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| DABIGATRAN (is an active metabolite)
| DABIGATRAN | BLOOD | - | Tmax 1 HOUR F 5 PERCENT VD 60 LITER PPB 35 PERCENT Cl 2.8 LITER / HOUR (EQN) HT 14.5 HOUR | PROTHROMBIN PDB 4JN2 (AN ANTIDOTE FOR DABIGATRAN) LIGAND CODE = 4CC (link to the list of PDB complexes) Download experimental 3D coordinates of 4CC with added hydrogens | Prothrombin UNIPROT P00734 F2 more at DrugCentral | EMA | |||
