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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| M ROFLUMILAST (is an active metabolite)
| ROFLUMILAST | RESPIRATORY | - | PPB 97 PERCENT HT 30 HOUR | PDE4 PHOSPHODIESTERASE 4 | Phosphodiesterase 4 UNIPROT P27815 PDE4A more at DrugCentral | EMA | |||
