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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| RUXOLITINIB
| RUXOLITINIB | ANTINEOPLASTIC AGENT | ORAL TOPICAL | VD 59 LITER PPB 97 PERCENT Cl 19.9 LITER / HOUR HT 3 HOUR SOLUBILITY SOLUBLE IN AQUEOUS BUFFERS ACROSS A PH RANGE OF 1 TO 8 | JANUS ASSOCIATED KINASES JAK1 JAK2 PDB 4U5J (C-SRC IN COMPLEX WITH RUXOLITINIB) LIGAND CODE = RXT (link to the list of PDB complexes) Download experimental 3D coordinates of RXT with added hydrogens | Tyrosine-protein kinase JAK1 UNIPROT P23458 JAK1 -- Tyrosine-protein kinase JAK2 UNIPROT O60674 JAK2 more at DrugCentral | EMA | |||
