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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
CLOBAZAM

CLOBAZAM


ATC N05BA09

NERVOUS SYSTEM
ANXIOLYTICS
ANTIEPILEPTIC
BENZODIAZEPINE DERIVATIVES
SEIZURES ASSOCIATED WITH LENNOX-GASTAUT SYNDROME
GABAA AGONIST

ORAL

F 100 PERCENT

VD 100 LITER

PPB 85 PERCENT

Cl 1.7 LITER / HOUR (EQN)

HT 39 HOUR

SOLUBILITY SLIGHTLY SOLUBLE IN WATER

GABAA RECEPTOR

GABA-A receptor alpha-1,beta-2,gamma-2 UNIPROT P14867 GABRA1

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