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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| LINAGLIPTIN
| LINAGLIPTIN |
METABOLISM | ORAL | Cmax 8.9 NANOMOLAR (5 MILLIGRAM) Tmax 1.5 HOUR F 30 PERCENT VD 1110 LITER PPB 84 PERCENT Cl 76 LITER / HOUR (EQN) HT 12 HOUR (5 MILLIGRAM) SOLUBILITY VERY SLIGHTLY SOLUBLE IN WATER 0.9 MILLIGRAM / MILLILITER | DPP-4 DIPEPTIDYL PEPTIDASE-4 PDB 2RGU (CRYSTAL STRUCTURE OF COMPLEX OF HUMAN DPP4 AND INHIBITOR) LIGAND CODE = 356 (link to the list of PDB complexes) Download experimental 3D coordinates of 356 with added hydrogens | Dipeptidyl peptidase 4 UNIPROT P27487 DPP4 more at DrugCentral | EMA | |||
