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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| VILAZODONE
| VILAZODONE | NERVOUS SYSTEM | ORAL | Cmax 0.35 MICROMOLAR (40 MILLIGRAM) Tmax 4.5 HOUR F 72 PERCENT PPB 98 PERCENT HT 25 HOUR | SEROTONIN REUPTAKE PDB 8FYL (VILAZODONE-BOUND SEROTONIN 1A (5-HT1A) RECEPTOR-GI1 PROTEIN COMPLEX) LIGAND CODE = YG7 (link to the list of PDB complexes) Download experimental 3D coordinates of YG7 with added hydrogens | Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 -- 5-hydroxytryptamine receptor 1A UNIPROT P08908 HTR1A more at DrugCentral | EMA | |||
