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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| EZOGABINE DISCONTINUED
| EZOGABINE | NERVOUS SYSTEM | ORAL | F 60 PERCENT VD 162.5 LITER (65 KILIGRAM) PPB 80 PERCENT Cl 32.5 LITER / HOUR (65 KILOGRAM) HT 9 HOUR SOLUBILITY IS PRACTICALLY INSOLUBLE IN AQUEOUS MEDIA AT PH VALUES ABOVE 4 - AT GASTRIC PH EZOGABINE IS SPARINGLY SOLUBLE IN WATER ABOUT 16 GRAM / LITER | KCNQ ION CHANNELS (KV7.2 TO 7.5) PDB 7CR7 (HUMAN KCNQ2-CAM IN COMPLEX WITH RETIGABINE) LIGAND CODE = FBX (link to the list of PDB complexes) Download experimental 3D coordinates of FBX with added hydrogens | Potassium voltage-gated channel subfamily KQT member 2 UNIPROT O43526 KCNQ2 -- Potassium voltage-gated channel subfamily KQT member 3 UNIPROT O43525 KCNQ3 more at DrugCentral | EMA | |||
