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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ERIBULIN
| ERIBULIN | ANTINEOPLASTIC AGENT | INTRAVENOUS | VD 135 LITER (0.25-4.0 MILLIGRAM / M2) PPB 57 PERCENT Cl 3.1 LITER / HOUR (0.25-4.0 MILLIGRAM / M2) HT 40 HOUR (0.25-4.0 MILLIGRAM / M2) | MICROTUBULES G2/M CELL-CYCLE BLOCK PDB 5JH7 (TUBULIN-ERIBULIN COMPLEX) LIGAND CODE = 6K9 (link to the list of PDB complexes) Download experimental 3D coordinates of 6K9 with added hydrogens | Tubulin beta UNIPROT P07437 TUBB more at DrugCentral | EMA | |||
