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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| PRALATREXATE
| PRALATREXATE | ANTINEOPLASTIC | INTRAVENOUS INJECTION | VD 37 LITER PPB 67 PERCENT Cl 11.46 LITER / HOUR HT 15 HOUR SOLUBILITY SOLUBLE IN AQUEOUS SOLUTIONS AT PH 6.5 OR HIGHER | DIHYDROFOLATE REDUCTASE FOLYLPOLYGLUTAMYL SYNTHETASE | Dihydrofolate reductase UNIPROT P00374 DHFR more at DrugCentral | EMA | |||
