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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| PITAVASTATIN
| PITAVASTATIN | HMG-COA REDUCTASE INHIBITOR | ORAL | F 51 PERCENT VD 148 LITER PPB 99 PERCENT Cl 8.5 LITER / HOUR (EQN) HT 12 HOUR SOLUBILITY VERY SLIGHTLY SOLUBLE IN WATER | 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE (HMG-COA) PDB 7ULM (COMPLEX OF HMG1 WITH PITAVASTATIN) LIGAND CODE = PV9 (link to the list of PDB complexes) Download experimental 3D coordinates of PV9 with added hydrogens | 3-hydroxy-3-methylglutaryl-coenzyme A reductase UNIPROT P04035 HMGCR more at DrugCentral | EMA | |||
