Browse e-DRUG3D database

Cheminformatic Tools and Databases for Pharmacology
Home	e-Drug3D	LEA3D	SENSAAS	IPMC

session 31815 - Total of 1 hits - Display hits per page:

Add another drug(s) by one keyword:
Exemple: “nib“ and click on the Search button (do not press Enter on the keyboard)

INN

Class

Route (list)

PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)

Primary Target and PDB code of Protein-Drug complex

Targets from DrugCentral

Links

ILOPERIDONE

ATC N05AX14

ANTIPSYCHOTIC
DOPAMINE ANTAGONIST
SEROTONIN ANTOGONIST
SCHIZOPHRENIA
NERVOUS SYSTEM
SEROTONIN 5-HT2A DOPAMINE D2 AND D3 RECEPTORS (KI VALUES OF 5.6, 6.3, 7.1,NM, RESPECTIVELY). MODERATE AFFINITY FOR DOPAMINE D4, SEROTONIN 5-HT6 AND 5-HT7RECEPTORS AND NOREPINEPHRINE NEAPLHA1 RECEPTORS (KI VALUES OF 25, 43, 22, AND 36 NM RESPECTIVELY), AND LOW AFFINITY FOR THE SEROTONIN 5HT1A, DOPAMINE D1, AND HISTAMINE H1 RECEPTORS (KI VALUES OF 168, 216 AND 473 NM, RESPECTIVELY). NO APPRECIABLE AFFINITY (KI>1000 NM) FOR CHOLINERGIC MUSCARINIC RECEPTORS.

ORAL

VD 2070 LITER

PPB 95 PERCENT

Cl 74.5 LITER / HOUR

HT 18 HOUR

SOLUBILITY PRACTICALLY INSOLUBLE IN WATER

DOPAMINE D2 (KI = 6.3 NANOMOLAR)
SEROTONIN 5-HT2A (KI = 5.6 NANOMOLAR)
DOPAMINE D3 (KI = 7.1 NANOMOLAR)

D(2) dopamine receptor UNIPROT P14416 DRD2 -- 5-hydroxytryptamine receptor 2A UNIPROT P28223 HTR2A

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank