| | ||||||||||
| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| METHYLPHENIDATE
| METHYLPHENIDATE | NERVOUS SYSTEM | ORAL TRANSDERMAL | Cmax 73 NANOMOLAR (20 MILLIGRAM) Tmax 6.8 HOUR F 23.5 PERCENT VD 169 LITER (65 KILOGRAM) PPB 15 PERCENT Cl 33 LITER / HOUR HT 3.2 HOUR SOLUBILITY FREELY SOLUBLE IN WATER | SODIUM-DEPENDENT NORADRENALINE TRANSPORTER SODIUM-DEPENDENT DOPAMINE TRANSPORTER SODIUM-DEPENDENT SEROTONIN TRANSPORTER | Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 -- Sodium-dependent dopamine transporter UNIPROT Q01959 SLC6A3 more at DrugCentral | EMA | |||
