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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| LACOSAMIDE
| LACOSAMIDE | NERVOUS SYSTEM | ORAL INTRAVENOUS | F 100 PERCENT VD 39 LITER (65 KILOGRAM) PPB 15 PERCENT Cl 2 LITER / HOUR (EQN) HT 13 HOUR SOLUBILITY SPARINGLY SOLUBLE IN WATER | VOLTAGE GATED SODIUM CHANNELS COLLAPSIN RESPONSE MEDIATOR PROTEIN-2 (CRMP-2) PDB 8S9B (CRYO-EM STRUCTURE OF NAV1.7 WITH LCM) LIGAND CODE = LQO (link to the list of PDB complexes) Download experimental 3D coordinates of LQO with added hydrogens | Sodium channel protein type 9 subunit alpha UNIPROT Q15858 SCN9A more at DrugCentral | EMA | |||
