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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
PLERIXAFOR

PLERIXAFOR


ATC L03AX16

IMMUNOMODULATING
IMMUNOSTIMULANTS
HEMATOPOIETIC STEM CEL1 MOBILIZER
CXCR4 CHEMOKINE RECEPTOR INHIBITOR THAT BLOCKS BINDING OF ITS COGNATE LIGAND: STROMAL CELL-DERIVED FACTOR-LALPHA (SDF-1ALPHA)

SUBCUTANEOUS

VD 19.5 LITER (65 KILOGRAM)

PPB 58 PERCENT

Cl 3.3 LITER / HOUR (EQN)

HT 4 HOUR (0.24 MILLIGRAM / KILOGRAM)

ALPHA-CHEMOKINE RECEPTOR CXCR4

PDB 8U4P (STRUCTURE OF AMD3100-BOUND CXCR4, GI COMPLEX)

LIGAND CODE = VH6 (link to the list of PDB complexes)

Download experimental 3D coordinates of VH6 with added hydrogens

C-X-C chemokine receptor type 4 UNIPROT P61073 CXCR4

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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