Cheminformatic Tools and Databases for Pharmacology

session 5451 - Total of 1 hits - Display   hits per page:

Add another drug(s) by one keyword:
Exemple: “nib“ and click on the Search button (do not press Enter on the keyboard)

1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
SAPROPTERIN

SAPROPTERINNATURAL MOLECULE (link)


ATC A16AX07

METABOLISM
AGONIST
TREATMENT OF HYPERPHENYLALANINAEMIA (HPA)
REDUCTION OF PHENYLALANINE CONCENTRATION IN PATIENTS WITH PHENYLKETONURIA (PKU)
COFACTOR FOR THE ENZYME PHENYLALANINE HYDROXYLASE (PAH). TREATMENT WITH BH4 CAN ACTIVATE RESIDUAL PAH AND IMPROVE THE NORMAL OXIDATIVE METABOLISM OF PHE, AND DECREASE PHE LEVELS
TREATMENT OF TETRAHYDROBIOPTERIN (BH4) DEFICIENCY

 ORAL

Tmax 3.5 HOUR

HT 6.7 HOUR

SOLUBILITY SOLUBLE IN WATER

 PHENYLALANINE HYDROXYLASE

 Phenylalanine-4-hydroxylase UNIPROT P00439 PAH

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank

Copyright © 2019 Université Côte d'Azur CNRS - All rights reserved
  | Contact |