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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ROTIGOTINE
| ROTIGOTINE | NERVOUS SYSTEM | TRANSDERMAL | Cmax 3.8 NANOMOLAR VD 5460 LITER (65 KILOGRAM) PPB 92 PERCENT Cl 630 LITER / HOUR (EQN) HT 6 HOUR | DOPAMINE RECEPTOR PDB 8IRT (DOPAMINE RECEPTOR D3R-GI-ROTIGOTINE COMPLEX) LIGAND CODE = R5F (link to the list of PDB complexes) Download experimental 3D coordinates of R5F with added hydrogens | D(2) dopamine receptor UNIPROT P14416 DRD2 more at DrugCentral | EMA | |||
