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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| TRIMETREXATE DISCONTINUED
| TRIMETREXATE | ANTIPARASITIC | INJECTION | VD 34.6 LITER PPB 95 PERCENT Cl 3.9 LITER / HOUR HT 11 HOUR SOLUBILITY TRIMETREXATE GLUCURONATE IS SOLUBLE IN WATER (> 50 MILLIGRAM / MILLILITER) WHEREAS TRIMETREXATE FREE BASE IS PRACTICALLY INSOLUBLE IN WATER (< 0.1 MILLIGRAM / MILLILITER) | DIHYDROFOLATE REDUCTASE (DHFR) PDB 1BZF (NMR SOLUTION STRUCTURE AND DYNAMICS OF THE COMPLEX OF LACTOBACILLUS CASEI DIHYDROFOLATE REDUCTASE WITH THE NEW LIPOPHILIC ANTIFOLATE DRUG TRIMETREXATE) LIGAND CODE = TMQ (link to the list of PDB complexes) Download experimental 3D coordinates of TMQ with added hydrogens | Dihydrofolate reductase UNIPROT P16184 more at DrugCentral | EMA | |||
