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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
SALMETEROL

SALMETEROL


ATC R03AC12
ATC R03AK12
ATC R03AK06

RESPIRATORY
SYMPATHOMIMETIC
BETA2-ADRENERGIC BRONCHODILATOR AGONIST

INHALATION

Cmax 0.36 NANOMOLAR (42 MICROGRAM TWICE DAILY)

PPB 96 PERCENT

HT 5.5 HOUR

SOLUBILITY SPARINGLY SOLUBLE IN WATER

BETA-2 ADRENERGIC RECEPTOR

PDB 6MXT (CRYSTAL STRUCTURE OF HUMAN BETA2 ADRENERGIC RECEPTOR BOUND TO SALMETEROL AND NB71)

LIGAND CODE = K5Y (link to the list of PDB complexes)

Download experimental 3D coordinates of K5Y with added hydrogens

Beta-2 adrenergic receptor UNIPROT P07550 ADRB2

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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