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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| GLYBURIDE
| GLYBURIDE | METABOLISM | ORAL | VD 5.2 LITER (65 KILOGRAM) PPB 97.9 PERCENT Cl 3.2 LITER / HOUR (65 KILOGRAM) HT 10 HOUR SOLUBILITY AQUEOUS SOLUBILITY INCREASES WITH PH AS A RESULT OF SALT FORMATION | ATP-SENSITIVE POTASSIUM CHANNEL OF THE PANCREATIC B-CELL PDB 5IFU (CRYSTAL STRUCTURE OF PROLYL-TRNA SYNTHETASE (PRORS, PROLINE--TRNA LIGASE) FROM PLASMODIUM FALCIPARUM IN COMPLEX WITH GLYBURIDE) LIGAND CODE = GBM (link to the list of PDB complexes) Download experimental 3D coordinates of GBM with added hydrogens | Sulfonylurea receptor 1, Kir6.2 UNIPROT Q09428 ABCC8 more at DrugCentral | EMA | |||
