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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that the equation t1/2 = VD / Cl * 0.693 was used | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| CEFADROXIL
| CEFADROXIL | ANTIINFECTIVES | ORAL | Cmax 7.71 MICROMOLAR (1 GRAM) VD 14.9 LITER (65 KILOGRAM) PPB 61 PERCENT Cl 9.7 LITER / HOUR (65 KILOGRAM) HT 1.1 HOUR SOLUBILITY SOLUBLE IN WATER | PENICILLIN-BINDING PROTEINS 1A/1B OLIGOPEPTIDE TRANSPORTER, SMALL INTESTINE ISOFORM OLIGOPEPTIDE TRANSPORTER, KIDNEY ISOFORM PDB 9BIR (CRYO-EM STRUCTURE OF THE MAMMALIAN PEPTIDE TRANSPORTER PEPT2 BOUND TO CEFADROXIL) LIGAND CODE = A1APP (link to the list of PDB complexes) Download experimental 3D coordinates of A1APP with added hydrogens | Bacterial penicillin-binding protein UNIPROT P02918 mrcA more at DrugCentral | EMA | |||
