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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
ACETAZOLAMIDE

ACETAZOLAMIDE


ATC S01EC01

SENSORY
CARBONIC ANHYDRASE INHIBITOR
ANTIGLAUCOMA
ANTICONVULSANTS
DIURETICS

ORAL INJECTION

Tmax 4.5 HOUR

F 100 PERCENT

VD 13 LITER (65 KILOGRAM)

PPB 93 PERCENT

Cl 1.1 LITER / HOUR (65 KILOGRAM)

HT 3.5 HOUR (PMID9650543)

SOLUBILITY VERY SLIGHTLY SOLUBLE IN WATER

CARBONIC ANHYDRASE

PDB 1AZM (DRUG-PROTEIN INTERACTIONS: STRUCTURE OF SULFONAMIDE DRUG COMPLEXED WITH HUMAN CARBONIC ANHYDRASE I)

LIGAND CODE = AZM (link to the list of PDB complexes)

Download experimental 3D coordinates of AZM with added hydrogens

Carbonic anhydrase 2 UNIPROT P00918 CA2 -- Carbonic anhydrase 1 UNIPROT P00915 CA1

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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