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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| SORAFENIB
| SORAFENIB | ANTINEOPLASTIC | ORAL | Tmax 3 HOUR F 43.5 PERCENT PPB 99.5 PERCENT HT 36.5 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | CRAF BRAF MUTANT BRAF KIT FLT-3 RET VEGFR-1 VEGFR-2 VEGFR-3 PDGFR-BETA PDB 1UWJ (THE COMPLEX OF MUTANT V599E B-RAF AND BAY439006.) LIGAND CODE = BAX (link to the list of PDB complexes) Download experimental 3D coordinates of BAX with added hydrogens | Platelet-derived growth factor receptor beta UNIPROT P09619 PDGFRB -- Mast,stem cell growth factor receptor Kit UNIPROT P10721 KIT more at DrugCentral | EMA | |||
