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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| TIOTROPIUM
| TIOTROPIUM |
RESPIRATORY | INHALATION | Cmax 0.010 NANOMOLAR F 19.5 PERCENT (INHALATION) AND 2.5 PERCENT (ORAL) VD 2080 LITER (65 KILOGRAM) PPB 72 PERCENT Cl 52.8 LITER / HOUR HT 132 HOUR SOLUBILITY SPARINGLY SOLUBLE IN WATER | MUSCARINIC ACETYLCHOLINE RECEPTOR (M1-M5) PDB 4DAJ (STRUCTURE OF THE M3 MUSCARINIC ACETYLCHOLINE RECEPTOR) LIGAND CODE = 0HK (link to the list of PDB complexes) Download experimental 3D coordinates of 0HK with added hydrogens | Muscarinic acetylcholine receptor M3 UNIPROT P20309 CHRM3 more at DrugCentral | EMA | |||
