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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ABACAVIR
| ABACAVIR |
ANTIINFECTIVES | ORAL | Cmax 10.4 MICROMOLAR (300 MILLIGRAM TWICE DAILY) F 83 PERCENT VD 55.9 LITER (65 KILOGRAM) PPB 50 PERCENT (INDEPENDENT OF CONCENTRATION) Cl 52 LITER / HOUR (65 KILOGRAM) HT 1.54 HOUR SOLUBILITY 77 MILLIGRAM / MILLILITER (LOGP = 1.20) | GLUCURONOSYLTRANSFERASE ALCOHOL DEHYDROGENASE GAG-POL POLYPROTEIN PDB 5U98 (THE CRYSTAL STRUCTURE OF A SELF-PEPTIDE COMPLEXED TO ABACAVIR AND HLA-B*57:01) LIGAND CODE = 1KX (link to the list of PDB complexes) Download experimental 3D coordinates of 1KX with added hydrogens | Reverse transcriptase,RNaseH UNIPROT Q72547 pol more at DrugCentral | EMA | |||
