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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| NELFINAVIR
| NELFINAVIR | ANTIINFECTIVES | ORAL | Cmax 7 MICROMOLAR (750 MILLIGRAM) VD 292 LITER (65 KILOGRAM) PPB 98 PERCENT Cl 47.6 LITER / HOUR (EQN) HT 4.25 HOUR SOLUBILITY SLIGHTLY SOLUBLE IN WATER AT PH < 4 | HIV-1 PROTEASE PDB 3EKX (CRYSTAL STRUCTURE OF THE WILD-TYPE HIV-1 PROTEASE WITH THE INHIBITOR, NELFINAVIR) LIGAND CODE = 1UN (link to the list of PDB complexes) Download experimental 3D coordinates of 1UN with added hydrogens | Pol polyprotein UNIPROT Q72874 pol more at DrugCentral | EMA | |||
